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Prostatic Artery Embolization beneficial for treating LUTS in

Prostatic Artery Embolization beneficial for treating LUTS in
Written by Dana Smith

Prostatic Artery Embolization is an effective option for treating lower urinary tract symptoms from Benign
Prostatic Hyperplasia in men with localized prostate cancer, suggests a study
published in the Journal of Vascular and Interventional Radiology (JVIR).

A study was conducted by a group of
researchers from Tampa, Florida, U.S.A, to evaluate the efficacy and safety of prostatic
artery embolization (PAE) on lower urinary tract symptoms (LUTS) in the setting
of localized prostate cancer.

The researchers conducted a retrospective,
single-center, institutional review board-approved study from December 2016 to
June 2020.

They selected a total of 21 patients
(median age, 72; range, 63–83 years) with moderate LUTS and localized prostate
cancer.

Clinical effectiveness was evaluated at
6 and 12 weeks using International Prostate Symptom Score (IPSS) and quality of
life (QoL) improvement.

Out of the total 21, Seventeen patients
were scheduled to receive definitive radiotherapy (RT) after Prostatic Artery
Embolization and 13 patients completed radiotherapy.

Short-term imaging signs of oncologic
progression was evaluated at 6 and 12 weeks defined by at least one of the
following on magnetic resonance imaging:

Ø Increased Prostate Imaging-Reporting and
Data System score of index lesion(s) to at least 4

Ø
New extracapsular extension

Ø
Seminal vesicle involvement

Ø Pelvic lymphadenopathy

Nonparametric Wilcoxon signed-rank test
was used for analysis.

The results of the study are as follows:

Ø International prostate symptom score (IPSS)
improved by a median of 12 and 14 at 6 and 12 weeks, respectively.

Ø
Quality of life improved by
a median of 2 and 3 at 6 and 12 weeks. Prostate volume decreased by a median of
24% and 36% at 6 and 12 weeks.

Ø
No patients demonstrated
disease progression at 6 or 12 weeks by imaging.

Ø No patients experienced increased
prostate-specific antigen after radiotherapy, grade ≥3 adverse events, or
greater genitourinary toxicity.

The researchers concluded that Prostatic
Artery Embolization is an efficient and safe treatment modality in men with Lower
Urinary Tract Symptoms developed due to benign prostatic hyperplasia in the setting of associated, localized, and non-obstructive Prostate cancer.

Reference:

A study titled, “Effectiveness and
Safety of Prostatic Artery Embolization for the Treatment of Lower Urinary
Tract Symptoms from Benign Prostatic Hyperplasia in Men with Concurrent
Localized Prostate Cancer” by Parikh N et. al published in Journal of Vascular
and Interventional Radiology (JVIR)

DOI:https://doi.org/10.1016/j.jvir.2021.03.534

Read original article here: Prostatic Artery Embolization beneficial for treating LUTS in

Read original article here: Prostatic Artery Embolization beneficial for treating LUTS in



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